| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Epirubicin |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually7-10days |
| Payment Terms: | L/C, D/A, D/P, T/T, Western Union, MoneyGram |
| Supply Ability: | 5000kg/Month |
| CAS: | 56420-45-2 | Mf: | C27H29NO11 |
|---|---|---|---|
| MW: | 543.5193 | Specification: | 98%-99% |
| Synonym: | Epirubicin | Appearance: | White Crystalline Powder |
CAS: 56420-45-2 API Antibiotic Antitumor Drugs Epirubicin
| CAS.No | 56420-45-2 |
| Product name | Epirubicin |
| MF | C27H29NO11 |
| MW | 543.52 |
| Boiling point | 617.77°C (rough estimate) |
The Introductction of Epirubicin
Epirubicin is an anthracycline drug used for chemotherapy. It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere.
Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage.
Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity. Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas.
The Application & Function of Epirubicin
It is used for breast cancer, ovarian cancer, digestive tract cancer (such as advanced gastric cancer, advanced colorectal cancer), malignant lymphoma, lung cancer and malignant melanoma.
Other Name of Epirubicin: Epirubicin, 10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-(8s-)oxy)-9;Epidoxorubicin;Farmarubicin;Farmarubicine;NSC 256942;Pharmarubicin;Pidorubicin;WP 697
The COA of Epirubicin
| Ref. Standard | According to enterprise internal control standard inspection | |
Results Of Analysis Tests |
||
Test |
Analysis Standard |
Results |
Description |
Powder |
Powder |
Identification |
(1)304nm,260nm. |
confirmed |
Melting Point |
192°C~196°C |
192°C~196°C |
Specific Rotation |
+124°~ +129° |
+127.1° |
(HPLC) Related substances |
(1)(Single):≤0.5% |
0.31% |
(2)(Total):≤1.0% |
0.59% |
|
Loss On Drying |
≤0.5% |
0.1% |
Assay |
≥98.5% |
99.5% |
Sieve analysis |
≤30μm |
confirmed |
Conclusion |
This product conforms to enterprise internal control standards |
|
