The Introductction of Inosine
Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.
Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs. Wobble base pairs for inosine and guanine.
Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from inosine monophosphate dehydrogenase (IMD) inhibition.
The Function&Application of Inosine
1. The inosine is used in the treatment of leucopenia and thrombocytopenia.
2. In the treatment of acute hepatitis and chronic hepatitis and liver cirrhosis, hepatic encephalopathy.
3. The inosine is used for coronary atherosclerotic heart disease (coronary heart disease), myocardial infarction, rheumatic heart disease, cor pulmonale auxiliary drug use.
4. The inosine is used to prevent and mitigate the schistosomiasis prevention drugs caused by the heart and the liver toxicity.
5. The inosine is used for eye diseases (central retinal inflammation, optic atrophy) auxiliary drug use.
The COA of Inosine