| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO, SGS |
| Model Number: | Chlorpheniramine Maleate |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Carton Box or Drum |
| Delivery Time: | Usually7-10days |
| Payment Terms: | L/C, D/P, D/A, T/T, , MoneyGram |
| Supply Ability: | 5000kg/Month |
| CAS: | 113-92-8 | Mf: | C20h23cln2o4 |
|---|---|---|---|
| MW: | 390.86 | Einecs: | 204-037-5 |
| Specification: | 98% | Certificate: | GMP/ISO9001 |
| High Light: | API Anti Allergy Powder,Anti Allergy Powder Chlorpheniramine Maleate,CAS 113-92-8 API Drug |
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CAS 113-92-8 API Antiallergic drugs Chlorpheniramine Maleate
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Product Name |
Chlorphenamine Maleate |
|
Synonyms |
1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate;1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate;2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1);Chlorophenamine;Chlorprophenpyridamine maleate;Cloropiril;Histadur |
|
CAS NO |
113-92-8 |
|
EINECS |
204-037-5 |
|
Molecular Formula |
C20H23ClN2O4 |
|
Molecular Weight |
390.86 |
|
Melting Point |
130-135 °C (lit.) |
|
Boiling Point |
N/A |
|
Flash Point |
9ºC |
|
Density |
1.1984 (rough estimate) |
|
Assay |
≥99% |
|
Grade |
Pharmaceutical Grade |
|
Solubility |
Freely soluble in water, soluble in ethanol (96 per cent) |
|
Appearance |
White Solid |
|
Storage |
2-8°C |
|
Usage |
Chlorpheniramine Maleate is an antagonist of the histamine H1-receptor |
The Introductction of Chlorphenamine Maleate
Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an is chemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.
The Function&Application of Chlorphenamine Maleate
Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.
This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms.
The COA of Chlorphenamine Maleate
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Testing Items |
Specifications |
Test Results |
|
Appearance |
White crystalline powder |
Confirm |
|
Identification |
IR:should be consistent with the IR references spectrum. |
Conform |
|
Solubility |
Easily soluble in water, ethanol or chlorofor, slightly soluble in ether. |
Confirm |
|
Loss on drying |
≤ 0.5% |
0.10% |
|
Residue on ignition |
≤ 0.1% |
0.01% |
|
PH |
4.0~5.0 |
4.6 |
|
Assay |
98.5%-102.0% |
99.8% |