Dietary Supplements Ingredients cas 489-32-7 Natural Epimedium Extract Icariin

Dietary Supplements Ingredients cas 489-32-7 Natural Epimedium Extract Icariin

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What is Epimedium Extract Icariin ?

Icariin is mainly found in the common flowering plant Epimedium, which is distributed in South China, southwest and northeast China, and is also cultivated in other countries such as Japan, South Korea and the United States. Icariin is widely used in traditional Chinese medicine for its functions of strengthening kidney Yang, anti-aging and enhancing immunity. According to modern research, Icariin contains many components, of which icariin is the most important and unique component. Icariin has a variety of biological activities, such as antibacterial, anti-inflammatory, reproductive system regulation, cardiovascular and cerebrovascular protection. In addition, icariin also contains flavonoids, alkaloids, polysaccharides and other components, they are also beneficial to the human body to a certain extent.

The Introduction of Epimedium Extract Icariin 2%-98%

This product is a dried aboveground part of the berberiferous plants Epimedium brevicornum maximum, Epimedium sagittatum (sieb. et zucc.) maximum, Epimedium pubescens maximum, Epimedium wushanense t.s.ying, or Epimedium nakai. Harvest when the stems and leaves are lush in summer and autumn, remove coarse stems and impurities, and extract ethanol after drying in the sun or in the shade.

Epimedium is a traditional Chinese medicine tonic that has the functions of tonifying the yang kidney, strengthening the bones, dispelling wind and dampness. It is used for erectile dysfunction, ejaculation, flaccidity of the bones, rheumatic pain, numbness, and contracture, as well as menopausal hypertension. It can effectively inhibit Staphylococcus and resist aging. Icariin is one of its effective ingredients, which can effectively improve the cardiovascular system, regulate endocrine function, and enhance endocrine function. Furthermore, it is particularly noteworthy that Epimedium also has anticancer effects and is hailed as the most promising anticancer drug

Epimedium Extract Icariin  Function and indications

Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoietic function, immune function and bone metabolism, and has the effects of tonifying kidney and strengthening Yang, anti-aging and anti-tumor.

1. Effect on endocrine:

Icariin can promote sexul function due to hypersecretion of semen, spermatocyst full, stimulation of sensory nerves, indirect excitement caused by sexul desire.

2. Impact on immune system function:

The number of T cells, turnover rate, antibody, antigen and phagocytosis function of reticuloendothelial system in patients with kidney deficiency are low, which can be improved by the treatment of kidney tonifying drugs such as Epimedium.

3, anti-aging effect:

Icariin can affect the aging mechanism from different aspects. For example, it affects cell passage, prolongs growth period, regulates immune and secretory systems, improves body metabolism and organ functions.

4. Effect on cardiovascular system:

Icariin has a certain protective effect on rat myocardial ischemia caused by pituitrin, and has obvious antihypertensive effect.

Advances in pharmacological action of Epimedium

Modern pharmacological studies have shown that the active components of Epimedium and their extracts have a wide range of physiological activities, and many new pharmacological effects and new uses have been found. In this paper, the progress of pharmacological effects of Epimedium in recent years is summarized as follows.

1 Pharmacological effects related to efficacy indications

1.1 Enhancement of gonadal function

The fluid extract of Epimedium has andn-like effects and can promote the secretion of semen in dogs. The content of plasma testostere (Ts) and the weight of testis and levator anal muscle in male mice were increased by intragastriction of herbi medium. The sex hormone activity of 20-40RAG extracted from Epimedium was equivalent to 7.5 g of testose. 125I radioimmunoassay was used to determine the effect of icariin at different concentrations on CGMP of PDE5 enzyme substrate in rabbit penile sponges. Icariin could increase the CGMP concentration in penile sponges in a concentration-dependent manner. The results indicated that the mechanism of icariin on penile erection was related to its ability to increase the concentration of CGMP and enhance the relaxation of penile cavernoid smooth muscle.

1.2 Regulate the body's immune function

Epimedium can enhance non-specific immune function and cellular immune function, and regulate humoral immune function. The effective components of epimedium are mainly icariin and epimedium polysaccharide. Both the polysaccharides and total flavonoids of Epimedium can significantly improve the phagocytosis rate and phagocytosis index of macrophages on chicken red blood cells, and can significantly antagonize the decreased phagocytosis function of mononuclear macrophages in mice induced by cyclophosphamide. It has bidirectional regulation on the secretion of interleukin-1 (IL-1) and tumor necrosis factor (TNF) by macrophages.

1.3 Promote bone growth

Epimedium has the effect of "reinforcing bone" and has good prevention and treatment of osteoporosis. The extract of Epimedium and the compound formulation containing epimedium have antagonistic effect on osteoporosis caused by long-term adrenal corticosteroids. In order to observe the effects of total flavonoids of epimedium on the functions of osteoblasts and osteoclasts, new sD rat osteoblasts and osteoclasts were obtained by enzymatic digestion and in vitro mechanical separation, respectively. The proliferation, differentiation and mineralization of osteoblasts were observed by adding different concentrations of total flavonoids of epimedium in culture medium. The number and morphology of osteoclasts were observed by tartrate-resistant acid phosphatase staining, and the number and area of bone absorption lacunae were analyzed by Image Pro plus. The results showed that total flavonoids of Epimedium could promote bone formation by affecting osteoblast proliferation, differentiation and mineralization, and decrease the number of osteoclasts in vitro and decrease the osteoclast absorption function.

1.4 Anti-aging

The experimental results showed that the function of T and B lymphocyte proliferation in subacute senescent mice induced by Dhalf lactose was decreased, and the total flavone of herbifi could significantly restore the function, significantly improve the activity of SOD in spleen, and reduce the formation of lipid peroxide and lipofuscin in heart and liver tissue of senescent mice. The polysaccharide and total flavone compound of epimedium can increase the level of monoamine neurotransmitter in hypothalamus of aged male rats, inhibit the activity of cholinesterase in brain of aged rats, increase the content of brain neurotransmitter acetylcholine, and improve the learning and memory ability of aged rats and mice, suggesting that total flavone of epimedium can significantly enhance the regulation function of neuroendocrine network in the body. Maintain the stability of the body's internal environment, thereby delaying aging.

1.5 Effects on cardiac and cerebrovascular systems

The total flavonoids of epimedium inhibited atrial muscle strength and frequency, and the dose-effect curve of isoproterenol on atrial muscle positive frequency shifted parallel to the right, but there was no calcium antagonism and M receptor activation effect. The results showed that total flavonoids of Epimedium selectively blocked myocardial pl receptor, but had no blocking effect on trachea receptor and vascular smooth muscle d receptor [. The myocardial contractile force was significantly increased by injecting the aqueous solution of epimedium and alcohol extract into the isolated toad heart, or injecting the aqueous solution of epimedium into the in-situ heart, and the myocardial contractile force was restored to the animal heart failure caused by pentobaral sodium. The aqueous decoction of epimedium with ethanol extract was injected intravenously into rabbits, rats and cats, which showed a hypotensive effect. The intraperitoneal injection of epimedium flavonoid glycosides could inhibit the rise of blood pressure in spontaneously hypertensive rats and reduce the mortality of the middle wind. The hypotensive effect of epimedium was mainly related to the expansion of peripheral blood vessels and the reduction of peripheral resistance, which caused 8. Although the extract of Epimedium could not completely counteract the experimental arrhythmia induced by strophanoside K and epinephrine in guinea pigs, it could significantly shorten the duration of the experimental arrhythmia. The cardiac perfusion of isolated animals (rabbits, guinea pigs) with the decoction of epimedium and alcohol extract can significantly increase coronary artery flow, and the intravenous injection of anesthetized dogs can also significantly increase coronary artery flow.

2 Other pharmacological effects

2.1 Antibacterial, antiviral and anti-inflammatory effects

In vitro experiments, Herba epimedium had strong inhibitory effect on Staphylococcus albus and Staphylococcus aureus. It had inhibitory effect on the tissue culture of spinal gray matter inflammation virus, E-CHO virus and Coxsackie virus. Subcutaneous injection of the methanol extract of Epimedium can significantly inhibit the foot swelling induced by egg white in rats, and reduce the capillary permeability induced by histamine in rabbits.

2.2 Lowering blood lipids and blood sugar

The experimental hyperlipidemia rabbits were administrated with the decoction of Epimedium water for 10 days, which had the effect of reducing the cholesterol and triglyceride of B monofat egg. It has obvious hypoglycemic effect on experimental hyperglycemic rats after gastric administration of epimedium extract.

2.3 Anti-tumor effect

The total flavonoids of Hermedium can significantly improve the phagocytic function of macrophages and the conversion rate of T lymphocytes in tumor-bearing mice, suggesting that it can promote the non-specific killing effect of macrophages on tumor cells and the specific cytotoxic effect of T lymphocytes, restore the low cellular immune function of tumor-bearing mice to a certain extent, and increase the ratio of spleen body. The garland rate of C3b receptor was significantly increased and the garland rate of immune complex was decreased. It is suggested that total flavone of Epimedium can increase the cellular and red cell immune function of tumor-bearing mice, and inhibit the growth of tumor cells to a certain extent.

3. Review and prospect

The pharmacological effects related to the effect of epimedium tonifying kidney Yang and strengthening muscles and bones are enhancing gonadal function, regulating immune function, promoting bone growth and delaying senescence. Epimedium also has strong heart, reduce blood pressure, anti-arrhythmia, increase cerebral blood flow, antibacterial, antiviral, anti-inflammatory, hypolipidemic, anti-tumor and other applications, with high medicinal and health care value. However, the current development and research is still in the initial stage, and the research on the effective components of Epimedium is not deep enough, and the microscopic mechanism of pharmacological action observed in the macro level needs to be further studied. Therefore, it is necessary to make use of the resource advantages of epimedium in China, combine traditional Chinese medicine experience with modern science and technology, and conduct in-depth research on its effective ingredients, preparation process, pharmacological action and clinical application. Epimedium may become a drug with good development prospects for enhancing immune function and immune regulation, anti-osteoporosis, and treating cardiovascular and cerebrovascular diseases. It has broad application prospect.

The COA of  Epimedium Extract Icariin

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