99% Orlistat Powder Weight Losing Raw Material CAS 96829-58-2

Weight Losing Raw Material 99% Orlistat Powder CAS 96829-58-2

The Introductction of Orlistat

Orlistat is currently an internationally recognized new weight loss and fat-lowering drug, marketed under the trade name Senicor.

Orlistat is a potent and long-acting specific gastrointestinal lipase inhibitor, by directly blocking the body's absorption of fat from food, once the caloric intake and fat is less than the consumption, the body fat is naturally reduced, thus achieving the purpose of weight loss. It is safe for weight loss, the active ingredients do not enter the blood circulation and do not act on the central nervous system, with fewer side effects, no dizziness, heartburn, insomnia, dry mouth, etc.

Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor, white or off-white powder at room temperature, insoluble in water, soluble in chloroform and readily soluble in ethanol, which inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the lumen of the stomach and small intestine. The fat in food cannot be broken down into free fatty acids and monoacylglycerols, and thus fat cannot be absorbed and utilized, thus reducing the body's caloric intake and controlling body weight.

Orlistat does not need to be absorbed systemically to be effective. At commonly used doses, fat absorption can be inhibited by up to 30%. It is rarely absorbed after oral administration and can be metabolically inactivated in the intestinal tract, with a metabolic site in the gastrointestinal tract wall and an elimination half-life of approximately 14 to 19 hours. About 97% of the product is excreted in the feces, of which 83% is excreted in its original form.

Orlistat is clinically used in obesity and hyperlipidemia. Generally, 120 mg can be taken orally three times a day during or 1 hour after meals. Weight loss can be started after 2 weeks of administration. It can be taken continuously for 6~12 months, and its effect will no longer be enhanced if the dose is increased to 400mg or more per day.

The Application & function of Orlistat

Orlistat reduces the absorption of dietary fat, resulting in weight loss.
Orlistat is a potent and selective inhibitor of gastric lipase and pancreatic lipase, but has no effect on other digestive enzymes (amylase, trypsin, chymotrypsin) and phospholipase, and does not affect the absorption of carbohydrates, proteins and phospholipids. It is not absorbed by the gastrointestinal tract and the inhibition of lipase is reversible.
Orlistat also has lipid-regulating effects: it reduces serum triglycerides (TG) and LDL-C and increases the ratio of HDL to LDL in obese patients.

Other Name of Orlistat

XENICAL
Orlistat
ORLISTAT
RO-18-0647
Orlipastat
Orlistat(synthesis)
Orlistat(FerMentation)
(-)-TETRAHYDROLIPSTATIN
(-)-Tetrahydrolipstatin(EquivalentToOrlistat)
(1S)-1-{[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-D-leucinate
N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER
[(1S)-1-[[(2S)-3-hexyl-4-oxo-oxetan-2-yl]methyl]dodecyl] (2S)-2-formamido-4-methyl-pentanoate
(S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER

The COA of Orlistat