---Objective:

To compare the efficacy and adverse reaction of tianeptine and fluoxetine in the treatment of depression.

---Methods:

Forty-four patients with depression were randomly divided into tianeptine or fluoxetine group for 6 weeks. The effect and adverse reaction were evaluated with Hamilton anxiety scale(HAMA), Hamilton depression scale(HAMD), clinical global impression severity of illness(CGI-SI) and treatment emergent symptom scale(TESS).

---Results:

There was no significant difference in efficacy between these two groups. Both are slight side effects.Conclusion:Two drugs have the similar effects in the treatment of depression. Tianeptine has slight side effects.

                                                                                                                                                                                                                                                                                                                         ---From China Minkang medical