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Amphotericin B
Author:Administrator   |   Release time:2017-07-25   |   Category:API   |   Click:1752
  • Amphotericin B

Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentousbacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more activein vivo. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.

1. For antifungal
2. For a variety of fungal infections, such as Cryptococcus neoformans, Candida albicans, capsular histoplasmosis, dermatitis dentist bacteria, Schenotia sclerotiorum, Mucor and Bacillus sp. Role or killing effect. Mainly used for deep fungal disease drug of choice.
3. polyene antifungal agents. And fungal cell membrane on the sterol binding, damage the permeability of the membrane, leading to bacteria within the potassium, nucleotides, amino acids and other leakage, damage the normal metabolism and play a bacteriostatic effect.

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